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Principal Investigator

Jochen D. Muehlschlegel, MD, MMSc, MBA, FAHA, FASA

BWH Distinguished Chair in Anesthesiology, Perioperative and Pain Medicine
Vice Chair of Research, Dept. of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital
Associate Professor of Anesthesiology, Harvard Medical School
Associate Member of Broad Institute of MIT/Harvard

Dr. Muehlschlegel is an attending cardiovascular anesthesiologist at Brigham and Women’s Hospital, where he serves as Vice Chair of research in the Department of Anesthesiology, Perioperative, and Pain Medicine. He is also an Associate Professor of Anaesthesia at Harvard Medical School and holds the BWH Distinguished Chair of Anesthesiology, Perioperative and Pain Medicine.

As a cardiac anesthesiologist with significant subspecialty training in all aspects of cardiac disease and transesophageal echocardiography, Dr. Muehlschlegel is a perioperative physician guiding the care of very sick patients with cardiovascular disease.

Dr. Muehlschlegel is an NIH-funded physician-scientist with an active laboratory examining the impact of genetic variation upon adverse cardiovascular events and their significance on a functional level. He is the principal investigator of the CABG Genomics study group and the PI of the NHLBI-sponsored TRANSCRIBE (transcriptomic analysis of left ventricular gene expression) study. Both studies aim to determine the relationship between genetic variation and perioperative myocardial injury in patients undergoing cardiac surgery. Dr. Muehlschlegel is also the principal investigator of the NHLBI-sponsored GENEXPRO Surg (Gene Expression Profiling in Subjects with Postoperative Atrial Fibrillation after Cardiac Surgery) which aims to characterize the left atrium, the site in proximity to the origination of atrial fibrillation, using a multi ‘omics approach.

Among his leadership roles, Muehlschlegel serves as the chair of the Society of Cardiovascular Anesthesiologists research committee and is a member of the Association of University Anesthesiologists, the Association of Cardiac Anesthesiologists, and on the leadership committee of the American Heart Association’s Council on Cardiovascular Surgery and Anesthesia. He is also an associate oral board examiner of the American Board of Anesthesiology, which will allow him to contribute to, and have a national impact on the specialty of anesthesiology.

  • Medical School: Albert Ludwigs University Freiburg, Germany (1994-2001)
  • Residency: University of Florida, Gainesville, FL (2002-2006)
  • Fellowship: Cardiac Anesthesia, Brigham and Women’s Hospital, Boston, MA (2006-2007)
  • Research training: Masters of Medical Science in translational genetics, Harvard Medical School, Boston, MA (2008-2010)

Current Lab Members

Mandana Yazdani, PhD
Research Scientist

Sameeksha Tiwari, PhD Postdoctoral fellow

Svetlana Gorbatov, BS, MPH
Research Assistant

Amanda Pang, BS

Former Lab Members

Ashley H. Choi, MBI
(Master of Biomedical Informatics)

Mahyar Heydarpour, MSc, PhD

Ian Kelly, Premed Student

James Gosnell, RN
Research Assistant

Recent Publications

1. Stone G, Choi A, Meritxell O, Gorham J, Heydarpour M, Seidman CE, Seidman JG,
Aranki SF, Body SC, Carey VJ, Raby BA, Stranger BE, Muehlschlegel JD. Sex
differences in gene expression in response to ischemia in the human left
ventricular myocardium. Hum Mol Genet. 2019 May 15;28(10):1682-1693.
PMID: 30649309;

2. Muehlschlegel JD, Burrage PS, Ngai JY, Prutkin JM, Huang CC, Xu X, Chae SH,
Bollen BA, Piccini JP, Schwann NM, Mahajan A, Ruel M, Body SC, Sellke FW, Mathew
J, O’Brien B. Society of Cardiovascular Anesthesiologists/European Association of
Cardiothoracic Anaesthetists Practice Advisory for the Management of
Perioperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery. Anesth
Analg. 2019 Jan;128(1):33-42. PMID: 30550473.

3. Heydarpour M, Ejiofor J, Gilfeather M, Stone G, Gorham J, Seidman CE, Seidman
JG, Yammine M, Body SC, Aranki SF, Muehlschlegel JD. Molecular Genetics of
Lidocaine-Containing Cardioplegia in the Human Heart During Cardiac Surgery. Ann
Thorac Surg. 2018 Nov;106(5):1379-1387. PMID: 30028983

4. Saddic LA, Nicoloro SM, Gupta OT, Czech MP, Gorham J, Shernan SK, Seidman CE,
Seidman JG, Aranki SF, Body SC, Fitzgibbons TP, Muehlschlegel JD. Joint analysis
of left ventricular expression and circulating plasma levels of Omentin after
myocardial ischemia. Cardiovasc Diabetol. 2017 Jul 7;16(1):87. PMID: 28687077

5. Kelly BJ, Ho Luxford JM, Butler CG, Huang CC, Wilusz K, Ejiofor JI, Rawn JD,
Fox JA, Shernan SK, Muehlschlegel JD. Severity of tricuspid regurgitation is
associated with long-term mortality. J Thorac Cardiovasc Surg. 2018
Mar;155(3):1032-1038.e2. PMID: 29246545

Jochen D. Muehlschlegel: Center for Perioperative Genomics

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