Srdjan S. Nedeljkovic, MD
Departments of Anesthesiology, Perioperative and Pain Medicine
Assistant Professor of Anesthesia | Harvard Medical School
Dr. Nedeljkovic is actively involved with a number of drug and equipment development companies to develop innovative pain therapeutics. He has been working with Vivozon, a drug development company from South Korea in initiating the first human clinical trial of a novel non-narcotic analgesic substance for postoperative pain. He has been working with Pacira Pharmaceuticals to conduct the first trials assessing the efficacy and safety of Exparel, a liposomal bupivacaine, preparation, as a nerve blocking agent. Recently, he has been working to assess the clinical efficacy of Exparel in an obstetrical population of women who have undergone Cesarean section.
Dr. Nedeljkovic is collaborating with Sorrento Pharmaceuticals to conduct the first human trial of epidural injection of resiniferitoxin, a novel substance that may create analgesia by permanently ablating A-delta and C-fiber nociceptors while preserving normal neurological function. Dr. Nedeljkovic is also in the process of initiating a trial to assess the clinical utility of pharmacogenomic testing both in the perioperative patient population and for patients who seek care in the pain management center. In these efforts, Dr. Nedeljkovic has established excellent collaborations with colleagues at Massachusetts General Hospital and also with other investigators nationally and internationally.
Recent completed projects include the Back Pain Outcomes Longitudinal Data Collection grant. This federally funded grant involved establishing a registry of patients age 65 and older who present with an initial onset of low back pain. Patients were assessed over the course of two years for clinical characteristics and treatment outcomes. Dr. Nedeljkovic is also one of the lead investigators of a study to assess the efficacy of epidural steroid injections for older adults with lumbar spinal stenosis, comparing outcomes between patients who received local anesthetic alone vs a combination of steroid and local anesthetic.